RPL13A Antibody

Size

100ug

Clone Number

Aliases

RPL13A antibody; 60S ribosomal protein L13a antibody; 23 kDa highly basic protein antibody; Large ribosomal subunit protein uL13 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P40429

Immunogen

Recombinant Human 60S ribosomal protein L13a protein (63-190AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IF; Recommended dilution: IF:1:50-1:200

Background

Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3\'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. Involved in methylation of rRNA.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

RPL13A

Research Areas

Epigenetics and Nuclear Signaling