RPGF6 Polyclonal Antibody

Ab type

Primary antibody

Background

Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,Contains 1 cyclic nucleotide-binding domain.,Contains 1 N-terminal Ras-GEF domain.,Contains 1 PDZ (DHR) domain.,Contains 1 Ras-associating domain.,Contains 1 Ras-GEF domain.,subcellular location:Upon binding to M-Ras, it translocates to the plasma membrane.,subunit:Interacts with the second PDZ domain of human PTP1e.,tissue specificity:Isoform 3 has highest expression levels in the brain, heart, liver, lung and placenta and is barely detectable in skeletal muscle, kidney and pancreas.,

Reactivity

Human, Rat, Mouse

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from human protein . at AA range: 460-540

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

synonyms

Rap guanine nucleotide exchange factor 6 ;PDZ domain-containing guanine nucleotide exchange factor 2;PDZ-GEF2;RA-GEF-2