Rpb1(Phospho Ser1619) Polyclonal Antibody

Ab type

Primary antibody

Background

This gene encodes the largest subunit of RNA polymerase II| the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition| this subunit| in combination with several other polymerase subunits| forms the DNA binding domain of the polymerase| a groove in which the DNA template is transcribed into RNA.

Reactivity

Human, Mouse, Rat, Monkey

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human POLR2A around the phosphorylation site of Ser1619. AA range:1585-1634

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

217206

synonyms

DNA-directed RNA polymerase II subunit RPB1; POLR2A; POLR2; DNA-directed RNA polymerase II subunit RPB1; RNA polymerase II subunit B1; DNA-directed RNA polymerase II subunit A; DNA-directed RNA polymerase III largest subunit; RNA-directed RNA polymerase II subunit RPB1