RNF5 Antibody

Size

100ul

Clone Number

Aliases

E3 ubiquitin protein ligase RNF5 antibody; E3 ubiquitin-protein ligase RNF5 antibody; G16 antibody; HsRma1 antibody; NG2 antibody; OTTHUMP00000029107 antibody; Protein G16 antibody; Ram1 homolog antibody; RING finger protein 5 antibody; RING5 antibody; RMA1 antibody; RNF 5 antibody; RNF5 antibody; RNF5_HUMAN antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q99942

Immunogen

Recombinant Human E3 ubiquitin-protein ligase RNF5 protein (1-120AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200

Background

Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin and Salmonella type III secreted protein sopA. May be involved in regulation of cell motility and localization of PXN/paxillin. Mediates the \\\'Lys-63\\\'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N. Mediates the \\\'Lys-48\\\'-linked polyubiquitination of TMEM173 at \\\'Lys-150\\\' leading to its proteasomal degradation; the ubiquitination occurrs in mitochondria after viral transfection and regulates antiviral responses.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

RNF5

Research Areas

Cancer; Cell biology; Immunology; Microbiology