RNF4 Antibody

Size

100ug

Clone Number

Aliases

E3 ubiquitin ligase RNF4 antibody; E3 ubiquitin protein ligase RNF4 antibody; Protein SNURF antibody; RES4 26 antibody; RING finger protein 4 antibody; Rnf4 antibody; RNF4_HUMAN antibody; SLX5 antibody; Small nuclear ring finger protein antibody; SNURF antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P78317

Immunogen

Recombinant Human E3 ubiquitin-protein ligase RNF4 protein (1-103AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background

E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates \'Lys-6\'-, \'Lys-11\'-, \'Lys-48\'- and \'Lys-63\'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

RNF4

Research Areas

Others