RNF11 Antibody

Size

100ul

Clone Number

Aliases

CGI 123 antibody; RING finger protein 11 antibody; RNF11 antibody; RNF11_HUMAN antibody; Sid 1669 antibody; SID1669 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9Y3C5

Immunogen

Recombinant Human RING finger protein 11 protein (1-154AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates \\\'Lys-63\\\' polyubiquitin chains on RIPK1 and catalyzes the formation of \\\'Lys-48\\\'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

RNF11

Research Areas

Epigenetics and Nuclear Signaling; Cell biology