RN103 Rabbit Polyclonal Antibody

Ab type

Primary antibody

Background

The protein encoded by this gene contains a RING-H2 finger| a motif known to be involved in protein-protein and protein-DNA interactions. This gene is highly expressed in normal cerebellum| but not in the cerebral cortex. The expression of the rat counterpart in the frontal cortex and hippocampus was shown to be induced by elctroconvulsive treatment (ECT) as well as chronic antidepressant treatment| suggesting that this gene may be a molecular target for ECT and antidepressants. The protein is a ubiquitin ligase that functions in the endoplasmic reticulum-associated degradation pathway. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream CHMP3 (charged multivesicular body protein 3) gene.

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from human RN103

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

75350

synonyms

RN103