RIPK3 Antibody

Size

100ug

Clone Number

Aliases

Receptor interacting protein 3 antibody; Receptor interacting serine threonine kinase 3 antibody; Receptor interacting serine/threonine protein kinase 3 antibody; Receptor-interacting protein 3 antibody; Receptor-interacting serine/threonine-protein kinase 3 antibody; RIP 3 antibody; RIP like protein kinase 3 antibody; RIP-3 antibody; RIP-like protein kinase 3 antibody; RIPK 3 antibody; RIPK3 antibody; RIPK3_HUMAN antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9Y572

Immunogen

Recombinant Human Receptor-interacting serine/threonine-protein kinase 3 protein (1-518AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC, IF; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IF:1:200-1:500

Background

Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

RIPK3

Research Areas

Cancer; Cell biology; Immunology; Signal transduction