Ripk1 Antibody, HRP conjugated

Size

100ug

Clone Number

Aliases

Ripk1 antibody; Rinp antibody; Rip antibody; Receptor-interacting serine/threonine-protein kinase 1 antibody; EC 2.7.11.1 antibody; Cell death protein RIP antibody; Receptor-interacting protein 1 antibody; RIP-1 antibody

Immunogen Species

Mus musculus (Mouse)

UniProt ID

Q60855

Immunogen

Recombinant Mouse Receptor-interacting serine/threonine-protein kinase 1 protein (1-656AA)

Raised in

Rabbit

Species Reactivity

Mouse

Tested Applications

ELISA

Background

Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at \'Ser-728\' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via \'Lys-63\'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex (By similarity). Interacts with ARHGEF2 (By similarity).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

HRP

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

Ripk1

Research Areas

Cancer; Cell biology; Signal transduction