RIPK1 Antibody

Size

100ug

Clone Number

Aliases

Cell death protein RIP antibody; FLJ39204 antibody; OTTHUMP00000039163 antibody; Receptor (TNFRSF) interacting serine threonine kinase 1 antibody; receptor interacting protein 1 antibody; Receptor interacting protein antibody; Receptor interacting protein kinase 1 antibody; Receptor interacting serine threonine protein kinase 1 antibody; Receptor TNFRSF interacting serine threonine kinase 1 antibody; Receptor-interacting protein 1 antibody; Receptor-interacting serine/threonine-protein kinase 1 antibody; Rinp antibody; RIP 1 antibody; RIP antibody; Rip-1 antibody; RIP1 antibody; RIPK 1 antibody; Ripk1 antibody; RIPK1_HUMAN antibody; Serine threonine protein kinase RIP antibody; Serine/threonine-protein kinase RIP antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q13546

Immunogen

Recombinant Human Receptor-interacting serine/threonine-protein kinase 1 protein (328-458AA)

Raised in

Rabbit

Species Reactivity

Human, Rat, Mouse

Tested Applications

ELISA, WB, IF; Recommended dilution: WB:1:500-1:5000, IF:1:200-1:500

Background

Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at \\\'Ser-728\\\' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via \\\'Lys-63\\\'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

RIPK1

Research Areas

Cancer; Cell biology; Signal transduction