RIN1 Antibody

Size

100ug

Clone Number

Aliases

RIN1 antibody; Ras and Rab interactor 1 antibody; Ras inhibitor JC99 antibody; Ras interaction/interference protein 1 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q13671

Immunogen

Recombinant Human Ras and Rab interactor 1 protein (192-341AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IF; Recommended dilution: IF:1:50-1:200

Background

Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

RIN1

Research Areas

Epigenetics and Nuclear Signaling; Neuroscience; Cancer; Signal transduction