RIC8A Antibody

Size

100ul

Clone Number

Aliases

MGC104517 antibody; MGC131931 antibody; MGC148073 antibody; MGC148074 antibody; Protein Ric-8A antibody; resistance to inhibitors of cholinesterase 8 homolog A (C. elegans) antibody; RIC8 antibody; RIC8A antibody; RIC8A_HUMAN antibody; Synembryn-A antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9NPQ8

Immunogen

Recombinant Human Synembryn-A protein (362-531AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

RIC8A

Research Areas

Signal transduction