RGS14 Antibody

Size

100ul

Clone Number

Aliases

Highly similar to rap1/rap2 interacting protein antibody; OTTHUMP00000223586 antibody; OTTHUMP00000223587 antibody; Regulation of G protein signaling 14 antibody; Regulator of G protein signaling 14 antibody; Regulator of G protein signalling 14 antibody; Regulator of G-protein signaling 14 antibody; RGS 14 antibody; RGS14 antibody; RGS14_HUMAN antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

O43566

Immunogen

Recombinant Human Regulator of G-protein signaling 14 protein (230-510AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB; Recommended dilution: WB:1:1000-1:5000

Background

Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o) alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory processing capacity and hippocampal-based learning and memory.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

RGS14

Research Areas

Signal transduction