RC3H2 Antibody, Biotin conjugated

Size

100ug

Clone Number

Aliases

2900024N03Rik antibody; 9430019J22Rik antibody; D930043C02Rik antibody; FLJ20301 antibody; FLJ20713 antibody; Membrane associated DNA binding protein antibody; Membrane associated nucleic acid binding protein antibody; Membrane-associated nucleic acid-binding protein antibody; MGC52176 antibody; MNAB antibody; OTTHUMP00000022076 antibody; OTTHUMP00000022077 antibody; OTTMUSP00000013545 antibody; OTTMUSP00000013546 antibody; Rc3h2 antibody; RC3H2_HUMAN antibody; Ring finger and CCCH type domains 2 antibody; RING finger and CCCH type zinc finger domain containing protein 2 antibody; Ring finger and CCCH-type zinc finger domain-containing protein 2 antibody; ring finger and CCCH-type zinc finger domains 2 antibody; RING finger protein 164 antibody; RNF164 antibody; roquin-2 antibody; RP23-321B3.1 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9HBD1

Immunogen

Recombinant Human Roquin-2 protein (251-506AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA

Background

Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3\'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation. May act as a ubiquitin E3 ligase. Involved in the ubiquitination of MAP3K5 (PubMed:24448648).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Biotin

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

RC3H2

Research Areas

Epigenetics and Nuclear Signaling