RBP4 Monoclonal Antibody

Size

100ug

Clone Number

6A1C2

Aliases

Plasma retinol-binding protein, PRBP, RBP, RBP4, PRO2222

Immunogen Species

Human

UniProt ID

P02753

Immunogen

Recombinant Human Retinol-binding protein 4 protein

Raised in

Mouse

Species Reactivity

Human,Mouse

Tested Applications

ELISA,WB,IHC;Recommended dilution:WB:1:500-1:5000,IHC:1:50-1:500

Background

Retinol (Vitamin A) is transported in the blood bound to its carrier protein, retinol-binding protein (RBP), also designated plasma retinol-binding protein (PRBP) or RBP4. A member of the lipocalin family, RBP conveys retinol from stores in the liver to peripheral tissues. In plasma, RBP binds transthyretin (TTR, formerly called prealbumin) to prevent glomerular filtration of low molecular weight RBP in the kidneys. The stability of this complex holds diagnostic importance because the molar ratio of RBP:TTR provides an indirect way to indicate marginal vitamin A deficiency. Vitamin A deficiency blocks the secretion of RBP resulting in defective delivery and supply to epidermal cells. Originally identified solely as a transporter protein, recent studies correlating increased levels of RBP expression in adipose tissue with insulin resistance have generated research into the possible roles the protein may play in the pathogenesis of type 2 diabetes and obesity.

Clonality

Monoclonal

Isotype

IgG1

Purification Method

>95%,Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

RBP4

Research Areas

Cancer?Cardiovascular;Metabolism;Signal transduction