RBM38 Antibody

Size

100ug

Clone Number

Aliases

CLL associated antigen KW 5 antibody; CLL-associated antigen KW-5 antibody; HSRNASEB antibody; RBM38 antibody; RBM38_HUMAN antibody; RNA binding motif protein 38 antibody; RNA binding protein 38 antibody; RNA binding region (RNP1; RRM) containing 1 antibody; RNA binding region containing protein 1 antibody; RNA-binding motif protein 38 antibody; RNA-binding protein 38 antibody; RNA-binding region-containing protein 1 antibody; RNPC1 antibody; SEB4 antibody; SEB4B antibody; SEB4D antibody; ssDNA binding protein SEB4 antibody; ssDNA-binding protein SEB4 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9H0Z9

Immunogen

Recombinant Human RNA-binding protein 38 protein (1-239AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background

RNA-binding protein that specifically bind the 3\'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Plays a role in myogenic differentiation.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

RBM38

Research Areas

Epigenetics and Nuclear Signaling; Cell biology; Developmental biology; Stem cells