RBL2 Antibody

Size

100ul

Clone Number

Aliases

130 kDa retinoblastoma associated protein antibody; 130 kDa retinoblastoma-associated protein antibody; IB4 antibody; p130 antibody; PPAR-alpha-interacting complex protein 128 antibody; PRB2 antibody; Rb2 antibody; Rbl2 antibody; RBL2_HUMAN antibody; RBR 2 antibody; RBR-2 antibody; RBR2 antibody; Retinoblastoma like 2 antibody; Retinoblastoma-like protein 2 antibody; Retinoblastoma-related protein 2 antibody; RIC128 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q08999

Immunogen

Recombinant Human Retinoblastoma-like protein 2 protein (417-616AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:200-1:500

Background

Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 \'Lys-20\' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

RBL2

Research Areas

Epigenetics and Nuclear Signaling; Cancer; Cell biology