RBCK1 Antibody

Size

100ug

Clone Number

Aliases

C20orf18 antibody; Chromosome 20 open reading frame 18 antibody; HBV associated factor 4 antibody; HBV-associated factor 4 antibody; Heme-oxidized IRP2 ubiquitin ligase 1 antibody; Hepatitis B virus X associated protein 4 antibody; Hepatitis B virus X-associated protein 4 antibody; HOIL 1L antibody; HOIL-1 antibody; HOIL-1L antibody; HOIL1 antibody; HOIL1L antibody; RanBP type and C3HC4 type zinc finger containing 1 antibody; RanBP-type and C3HC4-type zinc finger-containing protein 1 antibody; RBCC protein interacting with PKC1 antibody; Rbck1 antibody; RBCK2 antibody; RING finger protein 54 antibody; RNF54 antibody; UB7I3_HUMAN antibody; UBCE7IP3 antibody; Ubiquitin conjugating enzyme 7 interacting protein 3 antibody; Ubiquitin-conjugating enzyme 7-interacting protein 3 antibody; XAP3 antibody; XAP4 antibody; ZRANB4 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9BYM8

Immunogen

Recombinant Human RanBP-type and C3HC4-type zinc finger-containing protein 1 protein (162-261AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination. Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome. Component of the LUBAC complex which conjugates linear (\'Met-1\'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

RBCK1

Research Areas

Epigenetics and Nuclear Signaling; Cell biology