RBBP8 Antibody

Size

100ug

Clone Number

Aliases

COM1 antibody; COM1_HUMAN antibody; CtBP interacting protein antibody; CtBP-interacting protein antibody; CtIP antibody; DNA endonuclease RBBP8 antibody; JWDS antibody; RB binding protein 8 endonuclease antibody; RBBP-8 antibody; RBBP8 antibody; Retinoblastoma-binding protein 8 antibody; Retinoblastoma-interacting protein and myosin-like antibody; Rim antibody; SAE2 antibody; SCKL2 antibody; Sporulation in the absence of SPO11 protein 2 homolog antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q99708

Immunogen

Recombinant Human DNA endonuclease RBBP8 protein (126-331AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in processing meiotic and mitotic double-strand breaks (DSBs) by ensuring both resection and intrachromosomal association of the broken ends. Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage. Promotes microhomology-mediated alternative end joining (A-NHEJ) during class-switch recombination and plays an essential role in chromosomal translocations.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

RBBP8

Research Areas

Epigenetics and Nuclear Signaling; Cancer