Rb Polyclonal Antibody

Ab type

Primary antibody

Background

The protein encoded by RB1 (RB transcriptional corepressor 1) is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in RB1 are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

Reactivity

Human;Mouse;Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from the C-terminal region of human Rb.

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

106159

synonyms

RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110