RASSF1 Antibody

Size

100ug

Clone Number

Aliases

123F2 antibody; Cardiac specific ras association domain family 1 protein antibody; cardiac-specific ras association domain family 1 protein; 123F2 antibody; NORE2A antibody; OTTHUMP00000195503 antibody; OTTHUMP00000195504 antibody; OTTHUMP00000195505 antibody; OTTHUMP00000195507 antibody; Pancreas specific ras association domain family 1 protein antibody; Ras association (RalGDS/AF 6) domain family member 1 antibody; Ras association domain-containing protein 1 antibody; RASF1_HUMAN antibody; Rassf1 antibody; RASSF1A antibody; RDA32 antibody; REH3P21 antibody; Tumor suppressor protein RDA32 antibody; WUGSC:H_LUCA12.5 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9NS23

Immunogen

Recombinant Human Ras association domain-containing protein 1 protein (23-145AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

RASSF1

Research Areas

Epigenetics and Nuclear Signaling; Cancer; Signal transduction