RALA Antibody

Size

100ug

Clone Number

Aliases

MGC48949 antibody; Ral a antibody; Ral A protein antibody; RAL antibody; RALA antibody; RALA_HUMAN antibody; Ras family small GTP binding protein RALA antibody; RAS like protein A antibody; Ras related protein RalA antibody; Ras-related protein Ral-A antibody; v ral simian leukemia viral oncogene homolog A (ras related) antibody; v ral simian leukemia viral oncogene homolog A antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P11233

Immunogen

Recombinant Human Ras-related protein Ral-A protein (1-203AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:20-1:200

Background

Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

RALA

Research Areas

Epigenetics and Nuclear Signaling; Cancer; Signal transduction