Raf-B(Phospho Ser446) Polyclonal Antibody

Ab type

Primary antibody

Background

This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway| which affects cell division| differentiation| and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome| a disease characterized by heart defects| mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers| including non-Hodgkin lymphoma| colorectal cancer| malignant melanoma| thyroid carcinoma| non-small cell lung carcinoma| and adenocarcinoma of lung. A pseudogene| which is located on chromosome X| has been identified for this gene.

Reactivity

Human, Mouse

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human B-RAF around the phosphorylation site of Ser446. AA range:411-460

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

84437

synonyms

Serine/threonine-protein kinase B-raf; BRAF; BRAF1; RAFB1; Serine/threonine-protein kinase B-raf; Proto-oncogene B-Raf; p94; v-Raf murine sarcoma viral oncogene homolog B1