RAD51D Antibody

Size

100ul

Clone Number

Aliases

BROVCA4 antibody; DNA repair protein RAD51 homolog 4 antibody; HsTRAD antibody; OTTHUMP00000163851 antibody; OTTHUMP00000163852 antibody; OTTHUMP00000163853 antibody; R51H3 antibody; RA51D_HUMAN antibody; RAD51 homolog D (S. cerevisiae) antibody; RAD51 homolog D antibody; RAD51 like 3 (S. cerevisiae) antibody; RAD51 paralog D antibody; RAD51, S. cerevisiae, homolog of, D antibody; RAD51-like protein 3 antibody; Rad51l3 antibody; Recombination repair protein antibody; S. cerevisiae RAD51-like 3 antibody; TRAD antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

O75771

Immunogen

Recombinant Human DNA repair protein RAD51 homolog 4 protein (1-328AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

RAD51D

Research Areas

Epigenetics and Nuclear Signaling