Rabbit anti-human PTPRE Antibody

Size

100ul

Clone Number

Aliases

DKFZp313F1310 antibody; FLJ57799 antibody; FLJ58245 antibody; HPTPE antibody; Protein tyrosine phosphatase epsilon antibody; Protein tyrosine phosphatase receptor type E antibody; Protein tyrosine phosphatase receptor type epsilon antibody; Protein tyrosine phosphatase receptor type epsilon polypeptide antibody; Protein-tyrosine phosphatase epsilon antibody; PTPE antibody; Ptpre antibody; PTPRE_HUMAN antibody; R PTP Epsilon antibody; R-PTP-epsilon antibody; Receptor-type tyrosine-protein phosphatase epsilon antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P23469

Immunogen

Recombinant Human Receptor-type tyrosine-protein phosphatase epsilon protein

Raised in

Rabbit

Species Reactivity

Human, Mouse

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200

Background

Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity).Isoform 2 acts as a negative regulator of insulin receptor (IR) signaling in skeletal muscle. Regulates insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1), phosphorylation of protein kinase B and glycogen synthase kinase-3 and insulin induced stimulation of glucose uptake.Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca2+.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

PTPRE

Research Areas

Signal transduction