PIN1 Antibody

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, also called DOD, is an enzyme that in humans is encoded by the PIN1 gene. It binds to a subset of proteins and thus plays a role as a post-phosphorylation control in regulating protein function. Studies have shown that the deregulation of PIN1 may play a pivotal role in various diseases. Notably, up-regulation of may be implicated in certain cancers, and the down-regulation may be implicated in Alzheimers disease. Inhibitors of PIN1 may have therapeutic implications for cancer and immune disorders. PIN1 activity regulates the outcome of proline-directed kinase (e.g. MAPK, CDK or GSK3) signalling and consequently regulates cell proliferation (in part through control of cyclin D1 levels and stability) and cell survival. It also has an essential role in maintaining cell proliferation and regulating cyclin D1 function.