NUP98 Antibody

Nuclear pore complex protein Nup98 is a protein that in humans is encoded by the NUP98 gene. This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. NUP98 is a peripheral nucleoporin located at both the cytoplasmic and nuclear sides of the central channel of the NPC. Its phosphorylation is critical for NPC disassembly at the onset of mitosis. It plays roles in gene expression, mitotic checkpoint, and pathogenesis. Ligand blot analysis suggested that NUP98 can function as a docking protein for cytosol-mediated docking of import substrates. In addition to that, it is a target of the vesicular stomatitis virus M protein-mediated inhibition of mRNA nuclear export.