Plakoglobin Antibody (gamma Catenin)

Junction Plakoglobin (JUP), also known asgamma-catenin, is a protein that in humans is encoded by the JUP gene. It is a member of the catenin protein family and homologous tob-catenin, and it is mapped to 17q21.2. This gene encodes a major cytoplasmic protein that is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins. Additionally, Plakoglobin may have distinct roles in Wnt signaling and cancer via differential effects on downstream target genes.