SIP1 Antibody (ZEB2)

Zinc finger E-box-binding homeobox 2, also known as Smad Interacting Protein 1 (SIP1) or Zinc finger homeobox 1B (ZFHX1B), is a protein that in humans is encoded by the ZEB2 gene. The gene is a member of the ZEB1/Drosophila Zfh1 family of 2-handed zinc finger/homeodomain proteins and functions as a DNA-binding transcriptional repressor that interacts with activatedSMADs, the transducers ofTGF-betasignaling, and interacts with the nucleosome remodeling and histone deacetylation(NURD) complex. By radiation hybrid analysis, Nagase et al.(1998) mapped the gene to chromosome 2. Wakamatsu et al.(2001) mapped the gene to chromosome 2q22. Vandewalle et al.(2005) showed that expression of mouse Sip1 in human epithelial cells caused a morphologic change from an epithelial to a mesenchymal phenotype. Expression ofSNAI1in epithelial cells triggers an epithelial-mesenchyme transition. Beltran et al.(2008) showed that synthesis of SIP1 was upregulated following SNAI1 expression in human cell lines.