KLF5 Antibody

Kruppel-like factor 5 is a protein that in humans is encoded by the KLF5 gene. It is also known as BTEB2. This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. Suske et al.(2005) stated that the human gene maps to chromosome 13q21.33, and the mouse gene to chromosome 14E2.1. Sogawa et al.(1993) isolated a cDNA encoding KLF5. The predicted protein contains 3 consecutive zinc finger motifs near the C terminus. The zinc finger domains were 59% and 64% identical to those of Sp1 (189906) and BTEB1, respectively. Both KLF5 and Sp1 have a short basic region preceding the zinc finger motifs that may play an auxiliary role in DNA binding. The N-terminal region of KLF5 is proline rich. Recombinant KLF5 protein and Sp1 showed very similar DNA-binding specificity in vitro. When expressed in mammalian cells, KLF5 activated the transcription of a reporter gene fused to a GC box-containing promoter. Sogawa et al.(1993) also identified the rat homolog.