COX2 Antibody

Cyclooxygenase (COX) is the key enzyme in conversion of arachidonic acid to PGs. The COX2 gene encodes an inducible prostaglandin synthase enzyme that is overexpressed in adenocarcinomas and other tumors. Deletion of the murine gene in Min mice reduced the incidence of intestinal tumors, suggesting that it is required for tumorigenesis.