CUL1 Antibody

Cullin 1 is a human protein and gene from cullin family. This protein plays an important role in protein degradation and protein ubiquitination. This is an essential component of the SCF(SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. Human CUL1, but not the other closely related cullins 2, 3, 4A, and 5, selectively interacts with human SKP1.