Cdk2 Antibody

Cyclin-Dependent Kinase 2 is also know as p33. The protein is highly homologous to p34 (CDC2) kinase and more significantly homologous to Xenopus Eg1 kinase, suggesting thatCdk2is the human homolog of Eg1. The gene is mapped to 12q13, the same region to which theCdk4gene maps. Human Cyclin A binds independently to two kinases, p34/Cdc2) or p33/Cdk2. In adenovirus-transformed cells, the viral E1A oncoprotein seems to associate with p33/Cyclin A but not with p34(cdc2)/cyclin A. The gene for p33 shares 65% sequence identity with p34(cdc2). Cdk2 plays a unique role in cell cycle regulation of vertebrate cells.