Akt1 Antibody

PKB alpha also knows as V-AKT murine thymoma vial oncogene homolog 1(ATK1). AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and is abrogated by mutations in the pleckstrin homology domain of AKT1. The gene is mapped to chromosome 14q32.3. The protein is critical for ischemic and VEGF-mediated angiogenesis. It regulates pathological angiogenesis, vascular maturation and permeability in vivo.