PUMA Polyclonal Antibody

Ab type

Primary antibody

Background

BBC3 encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. BCL2 binding component 3 cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, BBC3 is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants.

Reactivity

Human;Mouse;Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human PUMA. AA range:120-169

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

20532/14459

synonyms

BBC3; PUMA; Bcl-2-binding component 3; JFY-1; p53 up-regulated modulator of apoptosis