PTPRJ Antibody

Size

100ul

Clone Number

Aliases

CD 148 antibody; CD148 antibody; CD148 antigen antibody; Density enhanced phosphatase 1 antibody; Density-enhanced phosphatase 1 antibody; DEP 1 antibody; DEP-1 antibody; HPTP eta antibody; HPTPeta antibody; Human density enhanced phosphatase 1 antibody; Protein tyrosine phosphatase eta antibody; Protein tyrosine phosphatase receptor type J antibody; Protein tyrosine phosphatase receptor type J polypeptide antibody; Protein-tyrosine phosphatase eta antibody; Protein-tyrosine phosphatase receptor type J antibody; PTPJ antibody; Ptprj antibody; PTPRJ_HUMAN antibody; R PTP Eta antibody; R-PTP-eta antibody; R-PTP-J antibody; Receptor type tyrosine protein phosphatase eta antibody; Receptor-type tyrosine-protein phosphatase eta antibody; SCC 1 antibody; SCC1 antibody; susceptibility to colon cancer 1; mouse; homolog of antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q12913

Immunogen

Recombinant Human Receptor-type tyrosine-protein phosphatase eta protein (140-370AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

PTPRJ

Research Areas

Signal transduction