PTPRC Monoclonal Antibody,Purified

Size

Clone Number

Aliases

Immunogen Species

Human

UniProt ID

P08575

Immunogen

Recombinant Protein

Raised in

Mouse

Species Reactivity

Human

Tested Applications

ELISA,IF,FC;Recommended dilution:IF:1:100-1:200

Background

4AA9 reacts with CD45, a 180-220 kDa leukocyte common antigen (LCA). CD45 antigen is expressed at high levels on all hematopoietic cells including T and B lymphocytes, monocytes, granulocytes, NK cells and dendritic cells, but is not expressed on non-hematopoietic cells. CD45 antibody has also been reported to react weakly with mature blood erythrocytes and platelets. CD45 is a protein tyrosine phosphatase receptor that is critically important for T and B cell antigen receptor-mediated activation.*Target of immunosuppresive antibody treatment.1. Knapp, W et al., eds. (1989)  Leucocyte Typing  IV: White Cell Differentiation Antigens, Oxford University Press, New York.2. Trowbridge, IS and Thomas, ML. (1993) Annu. Rev. Immunol. 12:85.3. Pulido, R et al., (1988) J. Immunol.  140:3851.4. Roach, T et al., (1997) Curr. Biol. 7:408.

Clonality

Monoclonal

Isotype

IgG2a

Purification Method

Affinity purified

Conjugate

Non-conjugated

Buffer

Phosphate-buffered solution, pH 7.4, containing 0.09% sodium azide

Form

liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

PTPRC

Research Areas

Immunology