PTPN12 Antibody

Size

100ug

Clone Number

Aliases

Protein tyrosine phosphatase G1 antibody; Protein tyrosine phosphatase non receptor type 12 antibody; Protein-tyrosine phosphatase G1 antibody; PTN12_HUMAN antibody; PTP PEST antibody; PTP-PEST antibody; PTPG1 antibody; Ptpn12 antibody; Tyrosine protein phosphatase non receptor type 12 antibody; Tyrosine-protein phosphatase non-receptor type 12 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q05209

Immunogen

Recombinant Human Tyrosine-protein phosphatase non-receptor type 12 protein (539-714AA)

Raised in

Rabbit

Species Reactivity

Human, Mouse, Rat

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500

Background

Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at \\\'Tyr-1112\\\', \\\'Tyr-1196\\\', and/or \\\'Tyr-1248\\\' (PubMed:27134172).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

PTPN12

Research Areas

Signal transduction