PTP22 Polyclonal Antibody

Ab type

Primary antibody

Background

PTPN22 encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The protein tyrosine phosphatase, non-receptor type 22 is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Reactivity

Human;Mouse;Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from the N-terminal region of human PTP22.

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

91705

synonyms

PTPN22; PTPN8; Tyrosine-protein phosphatase non-receptor type 22; Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP; Lymphoid phosphatase; LyP; PEST-domain phosphatase; PEP