PTP Alpha Polyclonal Antibody

Ab type

Primary antibody

Background

The protein encoded by PTPRA (protein tyrosine phosphatase, receptor type A) is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of PTPRA, which encode two distinct isoforms, have been reported.

Reactivity

Human;Mouse;Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from PTPα . at AA range: 730-810

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

90600

synonyms

PTPRA; PTPA; PTPRL2; Receptor-type tyrosine-protein phosphatase alpha; Protein-tyrosine phosphatase alpha; R-PTP-alpha