PTN Antibody

Size

100ug

Clone Number

Aliases

HARP antibody; HB-GAM antibody; HBBM antibody; HBGAM antibody; HBGF-8 antibody; HBGF8 antibody; HBNF antibody; HBNF-1 antibody; HBNF1 antibody; heparin affin regulatory protein antibody; Heparin binding growth associated molecule antibody; Heparin binding growth factor 8 antibody; Heparin binding neurite outgrowth promoting factor 1 antibody; Heparin-binding brain mitogen antibody; Heparin-binding growth factor 8 antibody; Heparin-binding growth-associated molecule antibody; heparin-binding neurite outgrowth promoting factor antibody; Heparin-binding neurite outgrowth-promoting factor 1 antibody; NEGF1 antibody; Neurite growth promoting factor 1 antibody; Neurite outgrowth-promoting factor; heparin-binding antibody; OSF-1 antibody; OSF1 antibody; Osteoblast-specific factor 1 antibody; pleiotrophin (heparin binding growth factor 8; neurite growth-promoting factor 1) antibody; Pleiotrophin antibody; PTN antibody; PTN_HUMAN antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P21246

Immunogen

Recombinant Human Pleiotrophin protein (33-168AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells (PubMed:1768439, PubMed:1733956). Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation (PubMed:11278720). Binds to cell-surface target proteins via their chondroitin sulfate groups (PubMed:26896299). Down-regulates PTPRZ1 activity (PubMed:16814777).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

PTN

Research Areas

Neuroscience; Cancer; Immunology; Signal transduction