PTF1A Antibody, Biotin conjugated

Size

100ug

Clone Number

Aliases

bHLH transcription factor p48 antibody; bHLHa29 antibody; Class A basic helix-loop-helix protein 29 antibody; Class II bHLH protein PTF1A antibody; Exocrine pancreas specific transcription factor p48 antibody; p48 DNA binding subunit of transcription factor PTF1 antibody; p48 DNA-binding subunit of transcription factor PTF1 antibody; PACA antibody; PAGEN2 antibody; Pancreas specific transcription factor 1a antibody; Pancreas transcription factor 1 subunit alpha antibody; Pancreas-specific transcription factor 1a antibody; PTF 1A antibody; PTF1 p48 antibody; PTF1-p48 antibody; Ptf1a antibody; PTF1A_HUMAN antibody; PTF1P48 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q7RTS3

Immunogen

Recombinant Human Pancreas transcription factor 1 subunit alpha protein (224-325AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA

Background

Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5\'-CANNTG-3\'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an important role in cerebellar development. Directly regulated by FOXN4 and RORC during retinal development, FOXN4-PTF1A pathway plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Biotin

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

PTF1A

Research Areas

Epigenetics and Nuclear Signaling; Neuroscience