PSTPIP1 Antibody

Size

100ul

Clone Number

Aliases

CD2 antigen binding protein 1 antibody; CD2 binding protein 1 antibody; CD2 cytoplasmic tail binding protein antibody; CD2-binding protein 1 antibody; CD2BP1 antibody; CD2BP1L antibody; CD2BP1S antibody; H PIP antibody; H-PIP antibody; HPIP antibody; PAPAS antibody; PEST phosphatase interacting protein 1 antibody; PEST phosphatase-interacting protein 1 antibody; PPIP1_HUMAN antibody; Proline serine threonine phosphatase interacting protein 1 antibody; Proline-serine-threonine phosphatase-interacting protein 1 antibody; PSTPIP antibody; Pstpip1 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

O43586

Immunogen

Recombinant Human Proline-serine-threonine phosphatase-interacting protein 1 protein (157-416AA)

Raised in

Rabbit

Species Reactivity

Human, Mouse

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200

Background

Involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation (By similarity). Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2. Also has a role in innate immunity and the inflammatory response. Recruited to inflammasomes by MEFV. Induces formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation. Regulates endocytosis and cell migration in neutrophils.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

PSTPIP1

Research Areas

Signal transduction