PSMB8 Antibody

Size

100ul

Clone Number

Aliases

ALDD antibody; D6S216 antibody; D6S216E antibody; Large multifunctional peptidase 7 antibody; Large multifunctional protease 7 antibody; LMP 7 antibody; LMP7 antibody; Low molecular mass protein 7 antibody; Low molecular weight protein 7 antibody; Macropain subunit C13 antibody; MGC1491 antibody; Multicatalytic endopeptidase complex subunit C13 antibody; NKJO antibody; OTTHUMP00000062981 antibody; Protease component C13 antibody; Proteasome (prosome macropain) subunit beta type 8 antibody; Proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) antibody; Proteasome beta 8 subunit antibody; Proteasome catalytic subunit 3i antibody; Proteasome component C13 antibody; Proteasome related gene 7 antibody; Proteasome subunit beta 5i antibody; Proteasome subunit beta 8 antibody; Proteasome subunit beta type 8 antibody; Proteasome subunit beta type antibody; Proteasome subunit beta type-8 antibody; Proteasome subunit beta-5i antibody; Proteasome subunit Y2 antibody; PSB8_HUMAN antibody; PSMB 8 antibody; PSMB5i antibody; PSMB8 antibody; Really interesting new gene 10 protein antibody; RING 10 antibody; RING10 antibody; Y2 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P28062

Immunogen

Recombinant Human Proteasome subunit beta type-8 protein (176-276AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

PSMB8

Research Areas

Cell biology