PSENEN Antibody

Size

100ul

Clone Number

Aliases

Gamma secretase subunit PEN 2 antibody; Gamma Secretase Subunit PEN2 antibody; Gamma-secretase subunit PEN-2 antibody; Hematopoietic stem/progenitor cells protein MDS033 antibody; MDS033 antibody; MSTP064 antibody; PEN 2 antibody; PEN2_HUMAN antibody; Presenilin Enhancer 2 antibody; Presenilin enhancer 2 homolog antibody; Presenilin enhancer protein 2 antibody; PSEN2 antibody; psenen antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9NZ42

Immunogen

Peptide sequence from Human Gamma-secretase subunit PEN-2 protein (39-57AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:200-1:500

Background

Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein) (PubMed:12522139, PubMed:12763021, PubMed:12740439, PubMed:12679784, PubMed:24941111). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity (PubMed:12522139, PubMed:12763021, PubMed:12740439, PubMed:12679784, PubMed:24941111).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

PSENEN

Research Areas

Neuroscience