PSEN1 Antibody

Size

100ul

Clone Number

Aliases

AD3 antibody; Ad3h antibody; FAD antibody; Homo Sapiens Clone CC44 Senilin 1 antibody; Presenilin-1 CTF12 antibody; Protein S182 antibody; PS 1 antibody; PS-1 antibody; PS1-CTF12 antibody; PSEN1 antibody; PSN1_HUMAN antibody; PSNL1 antibody; S182 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P49768

Immunogen

Recombinant Human Presenilin-1 protein (1-160AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200

Background

Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

PSEN1

Research Areas

Neuroscience; Cancer; Metabolism; Signal transduction