PSB11 Rabbit Polyclonal Antibody

Ab type

Primary antibody

Background

Proteasomes generate peptides that are presented by major histocompatibility complex (MHC) I molecules to other cells of the immune system. Proteolysis is conducted by 20S proteasomes| complexes of 28 subunits arranged as a cylinder in 4 heteroheptameric rings: alpha-1 to -7| beta-1 to -7| beta-1 to -7| and alpha-1 to -7. The catalytic subunits are beta-1 (PSMB6; MIM 600307)| beta-2 (PSMB7; MIM 604030)| and beta-5 (PSMB5; MIM 600306). Three additional subunits| beta-1i (PSMB9; MIM 177045)| beta-2i (PSMB10; MIM 176847)| and beta-5i (PSMB8; MIM 177046)| are induced by gamma-interferon (IFNG; MIM 147570) and are preferentially incorporated into proteasomes to make immunoproteasomes. PSMB11| or beta-5t| is a catalytic subunit expressed exclusively in cortical thymic epithelial cells (Murata et al.| 2007

Reactivity

Human, Mouse

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from human PSB11

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

33000

synonyms

PSB11