Proteasome alpha3 Rabbit Polyclonal Antibody

Ab type

Primary antibody

Background

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome| the immunoproteasome| is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family| that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified.

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from human Proteasome α3

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

28050

synonyms

Proteasome α3; Proteasome subunit alpha type-3; EC 3.4.25.1; Macropain subunit C8; Multicatalytic endopeptidase complex subunit C8; Proteasome component C8