PRNP Antibody

Size

100ug

Clone Number

Aliases

Alternative prion protein, major prion protein antibody; AltPrP antibody; ASCR antibody; CD230 antibody; CD230 antigen antibody; CJD antibody; GSS antibody; KURU antibody; Major prion protein antibody; p27 30 antibody; PRIO_HUMAN antibody; Prion protein antibody; Prion related protein antibody; PRIP antibody; PRNP antibody; PrP antibody; PrP27 30 antibody; PrP27-30 antibody; PrP33-35C antibody; PrPC antibody; PrPSc antibody; Sinc antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P04156

Immunogen

Recombinant Human Major prion protein (23-64AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background

Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as a agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

PRNP

Research Areas

Neuroscience; Stem cells