PRKACB Antibody

Size

100ug

Clone Number

Aliases

cAMP-dependent protein kinase catalytic beta subunit isoform 4ab antibody; cAMP-dependent protein kinase catalytic subunit beta antibody; KAPCB_HUMAN antibody; PKA C beta antibody; PKA C-beta antibody; PKACB antibody; Prkacb antibody; protein kinase A catalytic subunit beta antibody; Protein kinase cAMP dependent catalytic beta antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P22694

Immunogen

Recombinant Human cAMP-dependent protein kinase catalytic subunit beta protein (2-53AA)

Raised in

Rabbit

Species Reactivity

Human, Mouse, Rat

Tested Applications

ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200

Background

Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

PRKACB

Research Areas

Cancer; Metabolism; Signal transduction